Nomenclature

Gene Symbol
SNRNP70 (H. sapiens)
Other Gene Symbols
RNPU1Z, RPU1, SNRP70, Snp1, U1-70K
Full Name
small nuclear ribonucleoprotein 70kDa (U1)
Other Names
U1-70kD, U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa

Other Resources

Entrez: Gene Info
6625
Uniprot: Protein Info
RU17_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112509
PDB: Structures
2L5I, 2L5J, 3CW1, 3PGW
SpliProt3D: Structural Model
SNRNP70

Gene Product Info

Molecular Weight (kD)
51.6
Domains
RRM
Motifs
—
Features
—
Complex Association
A complex, B complex, U1 snRNP
Class / Family
U1 snRNP
Notes
—

Orthologs

Name Organism
SNP1 S. cerevisiae
usp101 S. pombe
snRNP-U1-70K D. melanogaster
K04G7.10 C. elegans
MAL13P1.338 P. falciparum

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SNRNP70 SNRPC Dervied from Literature — 19325628
SNRNP70 HTATSF1 Dervied from Literature — 11780068
SNRNP70 CHERP Y2H: Bidirectional 0.81 22365833
SNRNP70 PRPF40A Dervied from Literature — 15231748
SNRNP70 SRSF1 Dervied from Literature — 8139654, 9685421, 9799243
SNRNP70 SRSF2 Dervied from Literature — 8139654, 8261509
SNRNP70 SRSF6 Dervied from Literature — 8139654
SNRNP70 SRPK1 Dervied from Literature — 9472028, 12417631
SNRNP70 DDX17 Dervied from Literature — 12193588
SNRNP70 PRMT5 Y2H: Prey/Bait 0.9 22365833
SNRNP70 SRSF10 Dervied from Literature — 14765198

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
U1 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 161 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 76 21536652
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 67 17332742
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 38 16809785
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 38 27377154
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 23 18193060
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 23 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 19 27377154
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 18 19941820
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 17 18981222
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 15 18193060
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 14 16809785
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 12 18193060
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 12 22110043
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 11 18322460
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 11 17537823
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 11 21536652
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 11 27377154
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 10 18193060
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 10 16809785
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 10 16809785
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 7 27377154
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 6 18981222
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 5 11804584
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 5 19935684
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 5 24448447
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 4 18981222
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 4 17537823
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 4 22110043
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 4 24448447
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 3 20980672
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 2 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 2 20980672
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 1 19941820
H complex, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 1 18981222
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 1 19935684
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
H complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
EDC complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
U1 snRNP, S. pombe, (Newo et al 2007) S. pombe ■ 17264129
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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