Nomenclature

Gene Symbol
HNRNPC (H. sapiens)
Other Gene Symbols
C1, C2, HNRNP, HNRPC, MGC104306
Full Name
heterogeneous nuclear ribonucleoprotein C (C1/C2)
Other Names
hnRNP C, heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1/C2, nuclear ribonucleoprotein particle C1 protein, nuclear ribonucleoprotein particle C2 protein

Other Resources

Entrez: Gene Info
3183
Uniprot: Protein Info
HNRPC_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
109424
PDB: Structures
1TXP, 1WF2, 3LN4
SpliProt3D: Structural Model
HNRNPC

Gene Product Info

Molecular Weight (kD)
33.7
Domains
RRM
Motifs
Nuclear localization signal
Features
—
Complex Association
C complex, P complex
Class / Family
hnRNP
Notes
—

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
HNRNPC SF3B2 Y2H: Bait/Prey 0.81 22365833
HNRNPC PTBP2 Y2H: Bidirectional 0.62 22365833
HNRNPC HNRNPC Y2H: Homodimer 0.81 22365833
HNRNPC HNRNPC Dervied from Literature — 10772858, 16189514
HNRNPC HNRNPD Y2H: Bait/Prey 0.75 22365833
HNRNPC RALY Y2H: Prey/Bait 0.88 22365833
HNRNPC CELF1 Y2H: Bait/Prey 0.5 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 73 27377154
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 63 21536652
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 52 20980672
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 51 18322460
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 51 18322460
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 50 24448447
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 49 18981222
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 48 18322460
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 43 18322460
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 40 27377154
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 34 16809785
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 27 18322460
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 27 20980672
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 27 24448447
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 26 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 26 24448447
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 22 18981222
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 21 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 20 27377154
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 18 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 18 27377154
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 17 19761775
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 17 21536652
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 14 17537823
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011) H. sapiens 14 21526149
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 13 18193060
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 13 16809785
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 12 11991638
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 11 11991638
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 11 18193060
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 11 16809785
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 10 18193060
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 10 20980672
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 10 17537823
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 8 19761775
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 8 17332742
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 7 23345524
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 6 17095540
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 6 17095540
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 6 20980672
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 5 16809785
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 5 23345524
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 4 18193060
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 4 21526149
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
mRNP unspliced control, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
EDC complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
H complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens ■ 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens ■ 12226669
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens ■ 24448447

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