Nomenclature

Gene Symbol: PRP22 (S. cerevisiae)
Other Gene Symbols: —
Full Name: Prp22p
Other Names: PRP22, YER013W

Other Resources

Entrez: Gene Info: 856732
Uniprot: Protein Info: PRP22_YEAST
Organism-Specific Database: S000000815
BioGrid: Interaction Info: 36745
PDB: Structures: —
SpliProt3D: Structural Model: —

Gene Product Info

Molecular Weight (kD): 130.0
Domains: Helicase ATP-binding, Helicase C-terminal, S1 motif
Motifs: DEAH box
Features: —
Complex Association: C complex, P complex
Class / Family: Second step factors
Notes: —

Orthologs

Name	Organism
DHX8	H. sapiens
prp22	S. pombe
pea	D. melanogaster
EEED8.5	C. elegans
DHX8	G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name	Species	# Of Peptides	PubMed ID
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011)	S. pombe	234	21386897
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010)	H. sapiens	224	20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010)	H. sapiens	211	20980672
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008)	H. sapiens	201	18322460
C complex sample 2, H. sapiens, (Bessonov et al 2008)	H. sapiens	169	18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014)	H. sapiens	160	24448447
C complex sample 1, H. sapiens, (Bessonov et al 2008)	H. sapiens	129	18322460
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011)	S. pombe	109	21386897
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014)	H. sapiens	97	24448447
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010)	S. cerevisiae	69	20089683
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009)	S. cerevisiae	68	19941820
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011)	S. pombe	65	21386897
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009)	D. melanogaster	54	18981222
C complex on PM5, H. sapiens, (Agafonov et al 2011)	H. sapiens	51	21536652
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013)	H. sapiens	44	23345524
C complex, H. sapiens, (Ilagan et al 2009)	H. sapiens	40	19761775
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013)	H. sapiens	35	23345524
C complex, H. sapiens, (Jurica et al 2002)	H. sapiens	29	11991638
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009)	D. melanogaster	28	18981222
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009)	S. cerevisiae	24	19941820
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002)	S. pombe	16	11884590
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010)	H. sapiens	15	20980672
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003)	S. cerevisiae	13	12509417
C complex on AdML, maltose elute, H. sapiens, (Coltri et al 2011)	H. sapiens	13	21526149
C complex exons trimmed, H. sapiens, (Ilagan et al 2009)	H. sapiens	10	19761775
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008)	H. sapiens	9	18322460
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002)	H. sapiens	9	12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002)	H. sapiens	9	12226669
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014)	H. sapiens	9	24448447
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002)	S. cerevisiae	8	11884590
B complex sample 2, H. sapiens, (Bessonov et al 2008)	H. sapiens	7	18322460
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010)	S. cerevisiae	6	20089683
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010)	H. sapiens	6	20980672
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011)	H. sapiens	6	21526149
CACN-1 pulldown with FLAG-HA tandem affinity from C. elegans, C. elegans, (Doherty et al 2014)	C. elegans	6	24948787
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009)	D. melanogaster	5	18981222
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014)	H. sapiens	4	24448447
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009)	D. melanogaster	3	18981222
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002)	S. cerevisiae	2	11884590
Supraspliceosome, H. sapiens, (Chen et al 2007)	H. sapiens	2	17537823
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009)	D. melanogaster	2	18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009)	D. melanogaster	2	18981222
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	1	19935684
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011)	H. sapiens	1	21536652
B* complex, H. sapiens, (Makarov et al 2002)	H. sapiens	■	12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002)	H. sapiens	■	12176931