Nomenclature

Gene Symbol: SF3B5 (H. sapiens)
Other Gene Symbols: MGC3133, SF3b10, Ysf3
Full Name: splicing factor 3b, subunit 5, 10kDa
Other Names: SF3b10, pre-mRNA-splicing factor SF3b 10 kDa subunit, splicing factor 3B subunit 5

Other Resources

Entrez: Gene Info: 83443
Uniprot: Protein Info: SF3B5_HUMAN
Organism-Specific Database: —
BioGrid: Interaction Info: 123645
PDB: Structures: —
SpliProt3D: Structural Model: SF3B5

Gene Product Info

Molecular Weight (kD): 10.1
Domains: —
Motifs: —
Features: —
Complex Association: 17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex
Class / Family: 17S U2 snRNP
Notes: —

Orthologs

Name	Organism
YSF3	S. cerevisiae
splicing factor 3B	S. pombe
CG11985	D. melanogaster
CELE_B0495.6	C. elegans
SF3B5	G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name	Species	# Of Peptides	PubMed ID
17S U2 snRNP, H. sapiens, (Agafonov et al 2011)	H. sapiens	104	21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011)	H. sapiens	93	21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011)	H. sapiens	67	21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011)	H. sapiens	42	21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011)	H. sapiens	40	21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015)	H. sapiens	21	27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015)	H. sapiens	16	27377154
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009)	S. cerevisiae	9	19941820
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	9	19935684
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010)	H. sapiens	7	20980672
B complex sample 2, H. sapiens, (Bessonov et al 2008)	H. sapiens	7	18322460
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	7	19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	7	19935684
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010)	H. sapiens	6	20980672
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006)	H. sapiens	6	16809785
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	6	19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	5	19935684
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013)	H. sapiens	5	23345524
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015)	H. sapiens	5	27377154
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009)	D. melanogaster	4	18981222
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015)	H. sapiens	4	27377154
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009)	S. cerevisiae	3	19941820
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008)	H. sapiens	3	18193060
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006)	H. sapiens	3	16809785
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	3	19935684
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	3	19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	3	19935684
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013)	H. sapiens	3	23345524
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013)	S. cerevisiae	3	23431055
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013)	S. cerevisiae	3	23431055
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010)	S. cerevisiae	2	20089683
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009)	S. cerevisiae	2	19941820
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008)	H. sapiens	2	18193060
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008)	H. sapiens	2	18193060
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009)	H. sapiens	2	18981222
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010)	H. sapiens	2	20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010)	H. sapiens	2	20980672
Supraspliceosome, G. gallus, (Chen et al 2007)	G. gallus	2	17537823
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008)	H. sapiens	2	18193060
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006)	H. sapiens	2	16809785
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013)	S. cerevisiae	2	23431055
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013)	S. cerevisiae	2	23431055
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013)	S. cerevisiae	2	23431055
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009)	S. cerevisiae	1	19941820
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008)	H. sapiens	1	18322460
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009)	S. cerevisiae	1	19941820
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009)	S. cerevisiae	1	19941820
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009)	H. sapiens	1	18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009)	D. melanogaster	1	18981222
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013)	S. cerevisiae	1	23431055
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013)	S. cerevisiae	1	23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013)	S. cerevisiae	1	23431055
SF3b, H. sapiens, (Will et al 2002)	H. sapiens	■	12234937
U2 17S, H. sapiens, (Will et al 2002)	H. sapiens	■	12234937
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004)	H. sapiens	■	15146077
B* complex, H. sapiens, (Makarov et al 2002)	H. sapiens	■	12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002)	H. sapiens	■	12176931
A complex, H. sapiens, (Hartmuth et al 2002)	H. sapiens	■	12477934
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006)	H. sapiens	■	17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006)	H. sapiens	■	17114945
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	■	19935684
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009)	S. cerevisiae	■	19935684