Nomenclature

Gene Symbol
DHX15 (H. sapiens)
Other Gene Symbols
DBP1, DDX15, HRH2, PRP43, PRPF43
Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 15
Other Names
hPRP43 , ATP-dependent RNA helicase #46, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15, DEAD/H box-15, DEAH box protein 15, RNA helicase 2

Other Resources

Entrez: Gene Info
1665
Uniprot: Protein Info
DHX15_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
108029
PDB: Structures
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SpliProt3D: Structural Model
DHX15

Gene Product Info

Molecular Weight (kD)
90.9
Domains
Helicase ATP-binding, Helicase C-terminal
Motifs
DEAH box
Features
—
Complex Association
A complex, B complex
Class / Family
17S U2 snRNP associated
Notes
—

Orthologs

Name Organism
PRP43 S. cerevisiae
prp43 S. pombe
CG11107 D. melanogaster
F56D2.6 C. elegans
PFI0860c P. falciparum
DHX15 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
DHX15 DDX42 Y2H: Bait/Prey 1 22365833
DHX15 RBM17 Y2H: Bait/Prey 1 22365833
DHX15 RBM17 Pull-down — 22365833
DHX15 NKAP Y2H: Bait/Prey 0.96 22365833
DHX15 SUGP1 Y2H: Bait/Prey 0.5 22365833
DHX15 SUGP1 Pull-down — 22365833
DHX15 RBM5 Y2H: Bait/Prey 1 22365833
DHX15 RBM5 Pull-down — 22365833
DHX15 RBM10 Y2H: Bait/Prey 1 22365833
DHX15 RBM10 Pull-down — 22365833
DHX15 TRA2A Y2H: Bait/Prey 1 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 142 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 130 27377154
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 63 21536652
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 60 27377154
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 56 24448447
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 54 18322460
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 52 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 51 18322460
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 46 27377154
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 45 20980672
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 44 21536652
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 44 27377154
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 36 24448447
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 30 22110043
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 29 16809785
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 28 20980672
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 28 16809785
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 27 18322460
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 27 18322460
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 27 20980672
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 26 24448447
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 25 17537823
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 23 20980672
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 22 20089683
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 16 17332742
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 14 16809785
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 13 18193060
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 13 17537823
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 11 18981222
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 11 18193060
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 11 22110043
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 10 12226669
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 10 18193060
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 10 21536652
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 9 19941820
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 8 18193060
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 8 11991638
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 8 11991638
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 8 18981222
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 8 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 8 23345524
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 7 18981222
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 7 19935684
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 6 18193060
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 6 19761775
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 6 18193060
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 6 21536652
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 4 18981222
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 3 19761775
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae 2 20089683
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 2 16809785
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 1 22110043
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
EDC complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
H complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens ■ 24448447
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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