Nomenclature

Gene Symbol
DDX23 (H. sapiens)
Other Gene Symbols
MGC8416, PRPF28, U5-100K, U5-100KD, prp28
Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Other Names
U5-100kD, 100 kDa U5 snRNP-specific protein, DEAD box protein 23, PRP28 homolog, yeast, PRP28p homolog, U5 snRNP 100 kD protein

Other Resources

Entrez: Gene Info
9416
Uniprot: Protein Info
DDX23_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
114811
PDB: Structures
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SpliProt3D: Structural Model
DDX23

Gene Product Info

Molecular Weight (kD)
95.6
Domains
Helicase ATP-binding, Helicase C-terminal
Motifs
DEAD box, Q motif
Features
—
Complex Association
B complex, tri-snRNP, U5 snRNP
Class / Family
U5 snRNP
Notes
—

Orthologs

Name Organism
PRP28 S. cerevisiae
prp28 S. pombe
CG10333 D. melanogaster
F01F1.7 C. elegans
PFE0925c P. falciparum

View orthologs at Homologene

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 217 27377154
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 164 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 157 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 110 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 107 18322460
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 101 27377154
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 100 24448447
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 76 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 75 27377154
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 57 21536652
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 53 20980672
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 51 18322460
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 49 24448447
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 48 16809785
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 47 20980672
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 47 18322460
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 39 20980672
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 36 20980672
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 33 16809785
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 29 18322460
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 28 24448447
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 27 18981222
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 26 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 26 18981222
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 25 21536652
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 23 18981222
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 23 16809785
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 21 17537823
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 21 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 19 18981222
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 18 17537823
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 18 18981222
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 17 21536652
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 14 12226669
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 14 24448447
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 12 12226669
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 11 18322460
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 11 21536652
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 9 11991638
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 9 16809785
SKIP GST-tag pulldown, H. sapiens, (Zhang et al 2003) H. sapiens 8 12840015
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 3 19761775
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 3 19761775
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 3 18981222
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
H complex, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 2 12509417
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 2 22110043
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
tri-snRNP, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe ■ 11884590
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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