Nomenclature

Gene Symbol
HSPA8 (H. sapiens)
Other Gene Symbols
HSC54, HSC70, HSC71, HSP71, HSP73
Full Name
heat shock 70kDa protein 8
Other Names
HSP73, LPS-associated protein 1, N-myristoyltransferase inhibitor protein 71, constitutive heat shock protein 70, heat shock 70kd protein 10, heat shock cognate 71 kDa protein

Other Resources

Entrez: Gene Info
3312
Uniprot: Protein Info
HSP7C_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
109544
PDB: Structures
3AGY, 3AGZ, 3ESK, 3FZF, 3FZH
SpliProt3D: Structural Model
HSPA8

Gene Product Info

Molecular Weight (kD)
70.9
Domains
—
Motifs
—
Features
—
Complex Association
C complex, P complex
Class / Family
PRP19 complex
Notes
—

Orthologs

Name Organism
SSA4 S. cerevisiae
Hsc70-1 D. melanogaster
F26D10.3 C. elegans
HSPA8 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
HSPA8 SRRT Y2H: Prey/Bait 0.62 22365833
HSPA8 KIAA1967 Y2H: Bait/Prey 0.5 22365833
HSPA8 HSPA8 Dervied from Literature — 7578144, 11679576, 14993262
HSPA8 BAG2 Dervied from Literature — 9873016
HSPA8 BAG2 Y2H: Prey/Bait 1 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 32 16809785
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 27 21536652
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 27 27377154
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 24 20980672
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 23 20980672
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 22 17537823
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 22 18193060
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 20 18322460
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 20 16809785
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 19 19761775
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 19 23345524
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 19 24448447
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 18 23345524
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 17 24448447
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 17 27377154
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 13 18193060
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 10 19761775
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 10 11991638
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 9 18193060
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 9 18322460
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 8 18322460
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 8 21536652
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 7 18322460
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 7 11991638
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 6 21536652
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 5 18981222
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 5 18193060
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 5 16809785
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 4 17537823
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 4 18981222
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 3 21536652
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 3 24448447
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 2 17332742
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae ■ 11804584
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens ■ 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens ■ 12226669
CDC5L pulldown, H. sapiens, (Ajuh et al 1999) H. sapiens ■ 11101529
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae ■ 12509417

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