Nomenclature

Gene Symbol
DHX9 (H. sapiens)
Other Gene Symbols
DDX9, FLJ17406, LKP, NDH2, NDHII
Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 9
Other Names
DDX9, ATP-dependent RNA helicase A, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9, DEAH box protein 9, leukophysin, nuclear DNA helicase II

Other Resources

Entrez: Gene Info
1660
Uniprot: Protein Info
DHX9_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
108025
PDB: Structures
3LLM
SpliProt3D: Structural Model
DHX9

Gene Product Info

Molecular Weight (kD)
141.0
Domains
DRBM, Helicase ATP-binding, Helicase C-terminal
Motifs
DEIH box, Nuclear localization signal
Features
—
Class / Family
misc. proteins found irregularly with spliceosomes
Notes
—

Orthologs

Name Organism
mle D. melanogaster
T07D4.3 C. elegans

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
DHX9 SNRPB Dervied from Literature — 11149922
DHX9 SNRPD3 Dervied from Literature — 11149922
DHX9 SNRPB2 Dervied from Literature — 11149922
DHX9 DHX9 Dervied from Literature — 11402034, 12711669
DHX9 HNRNPK Y2H: Bait/Prey 0.5 22365833
DHX9 DDX5 Y2H: Bait/Prey 0.5 22365833
DHX9 RBM4 Y2H: Bait/Prey 0.5 22365833
DHX9 KHDRBS1 Y2H: Bait/Prey 1 22365833
DHX9 KHDRBS1 Dervied from Literature — 10951562
DHX9 SMN1 Dervied from Literature — 11149922

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 150 27377154
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 89 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 44 27377154
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 43 17537823
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 33 18981222
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 27 27377154
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 24 18981222
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 16 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 15 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 14 18322460
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 7 12226669
mRNP on short 5' exon, AdML, H. sapiens, (Merz et al 2007) H. sapiens 6 17095540
mRNP unspliced control, H. sapiens, (Merz et al 2007) H. sapiens 4 17095540
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 4 22110043
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 3 17537823
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 2 17095540
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 1 18322460
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 1 12226669
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 1 23345524
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945

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