Nomenclature

Gene Symbol
LSM2 (H. sapiens)
Other Gene Symbols
C6orf28, G7B, YBL026W, snRNP
Full Name
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Other Names
LSM2, U6 snRNA-associated Sm-like protein LSm2, protein G7b, small nuclear ribonuclear protein D homolog, snRNP core Sm-like protein Sm-x5

Other Resources

Entrez: Gene Info
57819
Uniprot: Protein Info
LSM2_HUMAN
Organism-Specific Database
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BioGrid: Interaction Info
121778
PDB: Structures
—
SpliProt3D: Structural Model
LSM2

Gene Product Info

Molecular Weight (kD)
10.8
Domains
—
Motifs
—
Features
—
Complex Association
B complex, tri-snRNP
Class / Family
LSm
Notes
—

Orthologs

Name Organism
LSM2 S. cerevisiae
lsm2 S. pombe
CG10418 D. melanogaster
T10G3.6 C. elegans
PFE1020w P. falciparum

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
LSM2 SNRPB Y2H: Bait/Prey 1 22365833
LSM2 SNRPD2 Dervied from Literature — 14667819, 15231747
LSM2 SNRPD2 Y2H: Bidirectional 1 22365833
LSM2 SNRPE Dervied from Literature — 14667819, 15231747
LSM2 LSM3 Dervied from Literature — 14667819, 15231747, 16169070, 16189514
LSM2 LSM3 Y2H: Bidirectional 1 22365833
LSM2 LSM6 Y2H: Bidirectional 1 22365833
LSM2 LSM7 Y2H: Bait/Prey 1 22365833
LSM2 LSM7 Dervied from Literature — 14667819, 15231747
LSM2 LSM8 Y2H: Bait/Prey 0.5 22365833
LSM2 LSM8 Dervied from Literature — 14667819, 15231747
LSM2 SF3B2 Y2H: Bait/Prey 0.8 22365833
LSM2 PRCC Y2H: Bidirectional 1 22365833
LSM2 SMN1 Dervied from Literature — 10851237

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 81 21536652
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 75 21536652
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 25 27377154
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 23 27377154
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 21 19935684
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 20 18322460
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 17 16809785
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 14 16809785
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 14 24448447
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 13 21536652
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 13 27377154
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 11 27377154
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 10 18322460
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 10 19935684
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 10 24448447
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 9 18981222
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 8 19941820
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 7 18981222
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 6 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 5 18981222
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 4 19941820
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 3 17537823
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 2 19941820
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 2 18322460
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 2 11804584
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 2 18981222
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 2 16809785
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 2 24448447
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 1 18981222
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 1 20980672
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 1 11991638
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 1 12509417
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 1 24448447
tri-snRNP, S. cerevisiae, (Gottschalk et al 1999) S. cerevisiae ■ 10449419
tri-snRNP, S. cerevisiae, (Stevens et al 1999) S. cerevisiae ■ 11720284
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931

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