Nomenclature

Gene Symbol
SNRPB (H. sapiens)
Other Gene Symbols
COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB'
Full Name
small nuclear ribonucleoprotein polypeptides B and B1
Other Names
SmB/B', B polypeptide of Sm protein, Sm protein B/B', sm-B/Sm-B', small nuclear ribonucleoprotein polypeptide B, small nuclear ribonucleoprotein polypeptides B and B'

Other Resources

Entrez: Gene Info
6628
Uniprot: Protein Info
RSMB_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
112512
PDB: Structures
1D3B, 2Y9A, 2Y9B, 2Y9C, 2Y9D
SpliProt3D: Structural Model
SNRPB

Gene Product Info

Molecular Weight (kD)
24.6
Domains
—
Motifs
—
Features
—
Complex Association
17S U2 snRNP, A complex, B complex, Bact complex, C complex, P complex, tri-snRNP, U1 snRNP, U4/U6 snRNP, U5 snRNP
Class / Family
Sm
Notes
—

Orthologs

Name Organism
SMB1 S. cerevisiae
smb1 S. pombe
SmB D. melanogaster
W08E3.1 C. elegans
SNRPB G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
SNRPB SNRPB Dervied from Literature — 11756452
SNRPB SNRPD3 Dervied from Literature — 10025403, 10322216, 10601333, 10725331, 10851237, 11748230, 11756452
SNRPB SNRPD3 Y2H: Prey/Bait 1 22365833
SNRPB LSM2 Y2H: Prey/Bait 1 22365833
SNRPB LSM8 Y2H: Bait/Prey 1 22365833
SNRPB CD2BP2 Dervied from Literature — 15105431, 16000308
SNRPB DHX9 Dervied from Literature — 11149922
SNRPB TCERG1 Dervied from Literature — 11604498
SNRPB PRMT5 Dervied from Literature — 11720283
SNRPB RBBP6 Dervied from Literature — 9010216
SNRPB SMN1 Dervied from Literature — 9323129, 10556282, 11720283

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
B complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 308 21536652
Bact complex on PM5-20, H. sapiens, (Agafonov et al 2011) H. sapiens 304 21536652
tri-snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 270 21536652
C complex on PM5, H. sapiens, (Agafonov et al 2011) H. sapiens 257 21536652
U1 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 254 21536652
17S U2 snRNP, H. sapiens, (Agafonov et al 2011) H. sapiens 233 21536652
A complex on MINX, H. sapiens, (Agafonov et al 2011) H. sapiens 221 21536652
Prp19 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 213 21386897
Cwf2 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 155 21386897
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 111 19935684
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 94 27377154
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 84 16809785
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 74 16809785
Prp17tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 68 21386897
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 62 27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 55 27377154
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 52 27377154
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 51 19935684
Bact complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 49 19941820
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 47 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 47 19935684
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 45 20980672
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 43 27377154
C complex 1M NaCl-washed core, H. sapiens, (Bessonov et al 2008) H. sapiens 42 18322460
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 39 16809785
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 39 19935684
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 36 20980672
ILS, released intron complex on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 35 23431055
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 35 27377154
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 34 18322460
C complex on ActinACAC, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 33 19941820
35S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 33 19935684
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 33 24448447
B complex sample 1, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 31 19941820
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 31 20980672
45SBact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 30 19935684
40S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 28 19935684
C complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 26 18322460
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 26 24448447
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 22 18322460
B complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 22 18981222
Urn1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 21 21386897
45S Bact complex, deltaPrp2 (+Prp2/Spp2) on M3Actin, 75 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 21 19935684
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 20 24448447
28S B* complex, deltaPrp2 +Prp2/Spp2/ATP on M3Actin, 500 mM KCl wash, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 19 19935684
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 18 18322460
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 18 20980672
Prp43 dissasociated ILS 11-12 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 18 23431055
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 17 16809785
Prp43 dissasociated ILS 5-6 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 17 23431055
C complex released in 1M NaCl, H. sapiens, (Bessonov et al 2008) H. sapiens 15 18322460
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 15 17332742
Bact complex, deltaPrp2 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 15 23431055
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 15 24448447
penta-snRNP, S. cerevisiae, (Stevens et al 2002) S. cerevisiae 14 11804584
EDC-A complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 14 18193060
Post-catalytic complex, deltaPrp22 on M3Actin7, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 13 23431055
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 12 18981222
C complex on Ftz, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
B complex on Zeste62, sample 3, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
B complex on Zeste62, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 12 18981222
Saf3 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 12 21386897
Prp43 dissasociated ILS 7-8 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 12 23431055
Prp43 dissasociated ILS 13-14 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 12 23431055
C complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
B complex on Zeste62, sample 1, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
B complex on Ftz, sample 2, D. melanogaster, (Herold et al 2009) D. melanogaster 11 18981222
Prp43 dissasociated ILS 3-4 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 11 23431055
Prp43 dissasociated ILS 15-16 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 11 23431055
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 10 18193060
B complex on Ftz, sample 1, H. sapiens, (Herold et al 2009) H. sapiens 10 18981222
EDC-A complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 10 18193060
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 9 18193060
C complex, H. sapiens, (Ilagan et al 2009) H. sapiens 9 19761775
C complex on ActinD31, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 9 19941820
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 9 17537823
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 9 18193060
Prp8 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 9 19789211
Prp43 dissasociated ILS 9-10 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 9 23431055
Bact complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 8 19941820
E-like complex (E') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
Dre4 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 7 21386897
U2/U5/U6 complex Cwc2-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 6 11884590
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 6 18193060
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 6 22110043
U2 snRNP IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 6 22110043
Prp43 dissasociated ILS 1-2 glycerol gradient fraction, S. cerevisiae, (Fourmann et al 2013) S. cerevisiae 6 23431055
U2/U5/U6 complex CDC5-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 5 11884590
Supraspliceosome, H. sapiens, (Chen et al 2007) H. sapiens 5 17537823
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 5 22110043
U2/U5/U6 complex Prp19-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 4 11884590
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 4 11991638
Saf1 tap-tag pulldown, S. pombe, (Ren et al 2011) S. pombe 4 21386897
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 4 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 4 23345524
U2/U5/U6 complex Snt309-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 3 11884590
B complex sample 2, S. cerevisiae, (Fabrizio et al 2009) S. cerevisiae 3 19941820
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 3 12226669
U2/U5/U6 complex Cwc1-tag, S. cerevisiae, (Ohi et al 2002) S. cerevisiae 2 11884590
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 2 12226669
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 2 11991638
Clf1p-pulldown, S. cerevisiae, (Wang et al 2003) S. cerevisiae 2 12509417
Cwc21 tap-tag pulldown, S. cerevisiae, (Khanna et al 2009) S. cerevisiae 2 19789211
C complex on AdML, 3M urea wash, H. sapiens, (Coltri et al 2011) H. sapiens 2 21526149
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
U2/U5/U6 complex CDC5-tag, S. pombe, (Ohi et al 2002) S. pombe 1 11884590
tri-snRNP, S. cerevisiae, (Gottschalk et al 1999) S. cerevisiae ■ 10449419
H complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
U11/U12 18S di-snRNP, H. sapiens, (Will et al 2004) H. sapiens ■ 15146077
U2 17S, H. sapiens, (Will et al 2002) H. sapiens ■ 12234937
delta prp2 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
E complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
U5 35S complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
tri-snRNP, S. cerevisiae, (Stevens et al 1999) S. cerevisiae ■ 11720284
EDC complex, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
A-like complex (A') Weri, H. sapiens, (Sharma et al 2008) H. sapiens ■ 18193060
delta prp22 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
H complex Weri, H. sapiens, (Sharma et al 2005) H. sapiens ■ 16109373
delta prp16 blocked spliceosome, S. cerevisiae, (Lardelli et al 2010) S. cerevisiae ■ 20089683
U1 snRNP, S. pombe, (Newo et al 2007) S. pombe ■ 17264129
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934
Prp1 tap-tag pulldown, S. pombe, (Carnahan et al 2005) S. pombe ■ 15755920
PSF-pulldown, without splicing substrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, without splicing substrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
PSF-pulldown, with AdMl splicing subtrate, 250 mM salt wash, H. sapiens, (Peng et al 2006) H. sapiens ■ 17114945
B complex on MINX-MS2, ATPgammaS block, 40S glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562
A complex on MINX-MS2, ATPgammaS block, glycerol gradient peak, H. sapiens, (Agafonov et al 2016) H. sapiens ■ 27411562

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