Nomenclature

Gene Symbol
DDX5 (H. sapiens)
Other Gene Symbols
DKFZp434E109, DKFZp686J01190, G17P1, HLR1, HUMP68
Full Name
DEAD (Asp-Glu-Ala-Asp) box helicase 5
Other Names
p68, ATP-dependent RNA helicase DDX5, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, DEAD box protein 5, DEAD box-5, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)

Other Resources

Entrez: Gene Info
1655
Uniprot: Protein Info
DDX5_HUMAN
Organism-Specific Database
—
BioGrid: Interaction Info
108021
PDB: Structures
3FE2
SpliProt3D: Structural Model
DDX5

Gene Product Info

Molecular Weight (kD)
69.1
Domains
Helicase ATP-binding, Helicase C-terminal
Motifs
DEAD box, Q motif
Features
—
Class / Family
pre-mRNA/mRNA binding proteins
Notes
—

Orthologs

Name Organism
DBP2 S. cerevisiae
dbp2 S. pombe
DDX5 G. gallus

View orthologs at Homologene

Interactions
(from Hegele et al, 2012)

Interacting Partner 1 Interacting Partner 2 Interaction Type Score PubMed ID
DDX5 WBP11 Y2H: Bait/Prey 0.5 22365833
DDX5 RBFOX2 Y2H: Bait/Prey 0.5 22365833
DDX5 DHX9 Y2H: Prey/Bait 0.5 22365833
DDX5 RBM10 Y2H: Bidirectional 1 22365833
DDX5 DDX17 Dervied from Literature — 12595555
DDX5 DDX17 Y2H: Bidirectional 0.75 22365833
DDX5 HNRNPA0 Y2H: Bait/Prey 0.75 22365833
DDX5 HNRNPH1 Y2H: Bait/Prey 0.5 22365833
DDX5 HNRNPH1 Dervied from Literature — 17643375
DDX5 HNRNPH3 Y2H: Bidirectional 1 22365833
DDX5 HNRNPK Y2H: Bidirectional 0.88 22365833
DDX5 KHDRBS1 Y2H: Bait/Prey 0.5 22365833
DDX5 HNRNPH2 Y2H: Prey/Bait 1 22365833
DDX5 RBM4 Y2H: Bidirectional 0.83 22365833

view interactions at SSPPIR...

Identified in the following experiments:

Name Species # Of Peptides PubMed ID
Bact complex, deltaPrp2 on M3Actin, Orbitrap, 0.25 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 24 19935684
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 21 24448447
B complex via tobramycin tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 19 16809785
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 17 27377154
Supraspliceosome, G. gallus, (Chen et al 2007) G. gallus 16 17537823
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010) H. sapiens 16 20980672
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 15 27377154
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010) H. sapiens 14 20980672
C complex on PM5, H. sapiens, (Bessonov et al 2010) H. sapiens 14 20980672
B complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 14 18322460
B complex sample 1, H. sapiens, (Bessonov et al 2008) H. sapiens 14 18322460
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 14 27377154
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 12 27377154
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 9 24448447
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015) H. sapiens 9 27377154
B complex via tobramycin tag, sample 1, H. sapiens, (Deckert et al 2006) H. sapiens 8 16809785
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015) H. sapiens 8 27377154
Mixed complexes Weri, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010) H. sapiens 7 20980672
A-like complex (A') HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 7 18193060
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014) H. sapiens 7 24448447
mRNP on BetaGlobin, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 6 17095540
C complex sample 2, H. sapiens, (Bessonov et al 2008) H. sapiens 6 18322460
A complex, H. sapiens, (Behzadnia et al 2007) H. sapiens 6 17332742
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002) H. sapiens 6 12226669
Bact complex, deltaPrp2 on M3Actin, Q-Tof, 1 pmol, S. cerevisiae, (Warkocki et al 2009) S. cerevisiae 6 19935684
E complex IP'd by antibody to U1A, H. sapiens, (Marakov et al 2011) H. sapiens 6 22110043
H complex, H. sapiens, (Jurica et al 2002) H. sapiens 5 11991638
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006) H. sapiens 5 16809785
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014) H. sapiens 5 24448447
B complex on Ftz, sample 2, H. sapiens, (Herold et al 2009) H. sapiens 4 18981222
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002) H. sapiens 4 12226669
C complex, H. sapiens, (Jurica et al 2002) H. sapiens 4 11991638
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007) H. sapiens 3 17095540
E-like complex (E') Weri, H. sapiens, (Sharma et al 2008) H. sapiens 3 18193060
C complex on AdML, 3'SS mut, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 3 23345524
P complex on AdML, short 3' exon, Velos, H. sapiens, (Ilagan et al 2013) H. sapiens 3 23345524
E complex IP'd by antibody to PRPF40A, H. sapiens, (Marakov et al 2011) H. sapiens 3 22110043
EDC-E complex HeLa, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
EDC-E complex Weri, H. sapiens, (Sharma et al 2008) H. sapiens 2 18193060
C complex exons trimmed, H. sapiens, (Ilagan et al 2009) H. sapiens 1 19761775
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
mRNP on AdML, H. sapiens, (Merz et al 2007) H. sapiens 1 17095540
B* complex, H. sapiens, (Makarov et al 2002) H. sapiens ■ 12411573
Mixed spliceosome complexes, H. sapiens, (Neubauer et al 1999) H. sapiens ■ 9731529
Mixed spliceosome complexes, H. sapiens, (Rappsilber et al 2002) H. sapiens ■ 12176931
A complex, H. sapiens, (Hartmuth et al 2002) H. sapiens ■ 12477934

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