Nomenclature

Gene Symbol: DDX3X (H. sapiens)
Other Gene Symbols: DBX, DDX14, DDX3, HLP2
Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
Other Names: DDX3, ATP-dependent RNA helicase DDX3X, CAP-Rf, DEAD box protein 3, X-chromosomal, DEAD box, X isoform, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3

Other Resources

Entrez: Gene Info: 1654
Uniprot: Protein Info: DDX3X_HUMAN
Organism-Specific Database: —
BioGrid: Interaction Info: 108020
PDB: Structures: 2I4I, 2JGN, 3JRV
SpliProt3D: Structural Model: DDX3X

Gene Product Info

Molecular Weight (kD): 73.2
Domains: Helicase ATP-binding, Helicase C-terminal
Motifs: DEAD box, Q motif
Features: —
Class / Family: pre-mRNA/mRNA binding proteins
Notes: —

Orthologs

Name	Organism
DBP1	S. cerevisiae
bel	D. melanogaster
Y54E10A.9	C. elegans
Y71H2AM.19	C. elegans
DDX3X	G. gallus

View orthologs at Homologene

Identified in the following experiments:

Name	Species	# Of Peptides	PubMed ID
B complex sample 1, H. sapiens, (Bessonov et al 2008)	H. sapiens	24	18322460
Pre-B complex Sample#2, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015)	H. sapiens	14	27377154
B complex Sample#2, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015)	H. sapiens	14	27377154
C complex on PM5, H. sapiens, (Bessonov et al 2010)	H. sapiens	11	20980672
B complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014)	H. sapiens	10	24448447
B complex sample 2, H. sapiens, (Bessonov et al 2008)	H. sapiens	9	18322460
Supraspliceosome, H. sapiens, (Chen et al 2007)	H. sapiens	9	17537823
Pre-B complex Sample#3, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015)	H. sapiens	9	27377154
mRNP on BetaGlobin, heparin treated, H. sapiens, (Merz et al 2007)	H. sapiens	7	17095540
Pre-B complex Sample#1, on MINX-MS2 stalled by DDX23 (hPrp28) depletion, H. sapiens, (Boesler et al 2015)	H. sapiens	7	27377154
mRNP on AdML, heparin treated, H. sapiens, (Merz et al 2007)	H. sapiens	6	17095540
B complex via MS2 tag, sample 2, H. sapiens, (Deckert et al 2006)	H. sapiens	6	16809785
Supraspliceosome, G. gallus, (Chen et al 2007)	G. gallus	5	17537823
Mixed spliceosome complexes on AdML, H. sapiens, (Zhou et al 2002)	H. sapiens	5	12226669
B complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014)	H. sapiens	5	24448447
C complex on PM5, sample 2, H. sapiens, (Schmidt et al 2014)	H. sapiens	5	24448447
B complex Sample#3, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015)	H. sapiens	5	27377154
C complex sample 2, H. sapiens, (Bessonov et al 2008)	H. sapiens	4	18322460
B complex Sample#1, on MINX-MS2 "kinetically" trapped, H. sapiens, (Boesler et al 2015)	H. sapiens	4	27377154
mRNP on BetaGlobin, H. sapiens, (Merz et al 2007)	H. sapiens	2	17095540
mRNP on AdML, H. sapiens, (Merz et al 2007)	H. sapiens	2	17095540
Bact complex on PM5-10, H. sapiens, (Bessonov et al 2010)	H. sapiens	2	20980672
Bact complex on PM5-20, H. sapiens, (Bessonov et al 2010)	H. sapiens	2	20980672
C complex on MINX-GG, H. sapiens, (Bessonov et al 2010)	H. sapiens	2	20980672
Mixed spliceosome complexes on Ftz, H. sapiens, (Zhou et al 2002)	H. sapiens	2	12226669
B complex via MS2 tag, sample 1, H. sapiens, (Deckert et al 2006)	H. sapiens	2	16809785
EDC complex, H. sapiens, (Sharma et al 2005)	H. sapiens	■	16109373
H complex, H. sapiens, (Sharma et al 2005)	H. sapiens	■	16109373
C complex on PM5, sample 1, H. sapiens, (Schmidt et al 2014)	H. sapiens	■	24448447